The innate immune cells use a host of pattern recognition receptors to sense and identify foreign parts of an invading pathogen, such as the DNA of a virus. The innate immune system includes fast-acting but non-specialized cells (macrophages, neutrophils, mast cells etc.) that provide the first line of defense against the millions of potential pathogens to which humans are constantly exposed. The lab of Andrea Ablasser at EPFL found that senescing cells use a mechanism of the innate immune system to regulate the secretion of inflammation-mediating molecules. But although we know how senescence increases the activity of the genes for these proteins, we know very little about how the entire process begins in the first place. The production of this "senescence-associated secretory phenotype" controls a number of biological processes such as wound healing and tissue repair, but also tumor formation and some age-related disorders. Selene has black hair with side-swept bangs aligned to the left.When cells senesce, they undergo profound changes, including the secretion of several inflammation-mediating proteins (cytokines, chemokines, extracellular-matrix proteins, growth factors). She sports a gray Z-Ring on her left arm. Selene wears a red flower-like toque on top of her head. Her clothes consist of a loose light cream colored t-shirt with light pink and gold flower patterns spread across it. The shirt is tied at the bottom and she wears a white tank top underneath it. She also wears small teal shorts and red and black Litten-themed shoes with large yellow laces. Selene wears a sleeveless orange shirt with a white trim. The straps of the shirt are also white, and red flowers dot the surface along with an opening resembling flower petals at the bottom. She wears puffy white shorts and black, green, and, white sandals. On her head, she wears a yellow pork-pie hat with a salmon pink flower in it. Like every other playable protagonist in the core games, Selene is silent and has no pre-existing personality. Except for some premade dialogue choices, she is completely mute. Unlike the previous few games (Omega Ruby, Alpha Sapphire, X and Y, etc.), she does not appear if the player does not choose to play as her. Therefore, it is nearly impossible to figure out her personality. If Selene is selected to be played, she is born in Kanto and travels to Alola with her mother. She talks to Professor Kukui over video chat at the beginning of the game. Not much else is known about her, other than the fact that she is very young. She is at least 11, though, as she is able to partake in the Island challenges. Over the course of the game, Selene makes some new friends. She befriends Hau and Lillie, and meets her Cosmog, Nebby. She travels around the region, simultaneously enjoying her vacation and beating back Team Skull at the same time. Please help the Pokémon Wiki by expanding it.
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